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KMID : 0363220090470010084
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Korean Journal of Dermatology
2009 Volume.47 No. 1 p.84 ~ p.88
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A Case of Primary Cutaneous Anaplastic Large Cell Lymphoma Mimmicking Keratoacanthoma
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Kim Sang-Tae
Baek Jae-Woo
Kim Tae-Kwon
Lee Jin-Woo
Roh Hyo-Jin
Jeon Young-Seung
Suh Kee-Suck
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Abstract
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Pseudoepitheliomatous hyperplasia with a massive neutrophil infiltrate associated with primary cutaneous anaplastic
large cell lymphoma has been rarely reported. Herein we report on a 33-year-old man who presented with multiple
asymptomatic erythematous walnut-sized rapidly growing tumors on the axilla, trunk and left inguinal area for 1
month. The histopathologic features showed a keratoacanthoma-like epithelial hyperplasia in the epidermis and
several large atypical lymphoid cells with nuclear plemorphism and abundant cytoplasm in the dermis. The atypical
cells were obscured by a rich infiltrate of neutrophils and some eosionophils. Immunohistochemical studies
confirmed the majority of the large anaplastic cells in the dermis were CD30＋ cells. In addition, the expressions
of anaplastic lymphoma kinase (ALK) and epithelial membrane antigen (EMA) were negative. There was no
evidence of extracutaneous involvement. The patient was diagnosed with primary cutaneous anaplastic large cell
lymphoma (ALCL) and he was treated with low dose methotrexate (15 mg/week). We think that this case was
challenging both clinically and histologically.
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KEYWORD
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Anaplastic Large cell Lymphoma, ALCL, CD30, Pseudoepitheliomatous hyperplasia
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